Chromatin-level regulation of biosynthetic gene clusters.

نویسندگان

  • Jin Woo Bok
  • Yi-Ming Chiang
  • Edyta Szewczyk
  • Yazmid Reyes-Dominguez
  • Ashley D Davidson
  • James F Sanchez
  • Hsien-Chun Lo
  • Kenji Watanabe
  • Joseph Strauss
  • Berl R Oakley
  • Clay C C Wang
  • Nancy P Keller
چکیده

Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.

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عنوان ژورنال:
  • Nature chemical biology

دوره 5 7  شماره 

صفحات  -

تاریخ انتشار 2009